The mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor.
Payment
eBioChem Escrow service is especially designed for online transaction. You, as a buyer, will pay the Supplier ONLY after you receive the item(s) and are satisfied with the item(s). This value-added service is absolutely FREE and is available for all transactions at eBioChem.com.
Payment Method
Alipay:
Alipay can support the domestic Union pay card with RMB payment
payPal:
Credit Card:
Paypal can support all of the foreign credit card payment
