Applications:
1. Mangostin is a kind of xanthones able to scavenge free
radicals, a high ranker on the ORAC antioxidant scale.
Remarkable antioxidant activity superior than Vitamins
and abilities of anti-inflammatory, anti-tumor, anti-malaria
and phytoestrogen effect and antimicrobial activity against
fungi or bacteria.
2. Mangostin is used to treat skin infections, wounds,and
diarrhea. Alpha-mangostin, a xanthone, inhibited growth
of human leukemia HL60 cells, reduced the synthesis of
prostaglandins, and prevented oxidative damage of LDL in
vitro.
3. There is also preliminary evidence that alpha- and gamma-
mangostins act as histamine and serotonin receptor
blockers, and also inhibit HIV-1 protease. Garcinone E,
another xanthone, exerts cytotoxic effects against human
hepatocellular carcinoma cells. Extract from the pericarp of
mangosteen has antiproliferative, antioxidative, and apoptotic
effects against human breast cancer SKBR3 cells.
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