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You are here: Home >Reagents> General Reagents > HER-2基因扩增检测试剂盒
wholesale HER-2基因扩增检测试剂盒
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HER-2基因扩增检测试剂盒 Detail
产品名称:HER-2基因扩增检测试剂盒
规格:5人份,10人份,20人份
适用样本:中性福尔马林固定石蜡包埋的组织样本切片
产品描述
        HER-2(酪氨酸激酶-人类表皮生长因子受体2), 又名HER2/neu,c-erbB-2, CD340, 在20–30%的浸润性乳腺癌中存在扩增,常见的扩增有单纯的Her-2基因扩增,也存在17号染色体非整倍性导致的Her-2基因拷贝数增加。 HER-2阳性的乳腺癌浸润性强,无病生存期短,预后差。 
        曲妥珠单抗(赫赛汀)是一种重组DNA衍生的人源化单克隆抗体,适用于HER-2过度表达的乳腺癌。由于只有HER-2过度表达和基因扩增的乳腺癌患者用曲妥珠单抗治疗才有效。因此,正确的判断Her-2基因状态,可以准确的判断患者预后,并能指导临床合理选择治疗药物。
        目前通常使用的免疫组织化学方法无法区分HER-2蛋白为中度阳性的患者是否存在HER-2基因的扩增,直接检测HER-2基因扩增水平的荧光原位杂交被认为是检测乳腺癌HER-2基因扩增的"金标准"。
        本品以确诊为乳腺癌患者的石蜡包埋乳腺癌组织切片为检测对象,用FISH的方法检测乳腺癌细胞中HER-2/neu基因(17q12)的扩增,作为判断预后以及指导乳腺癌药物治疗,尤其是抗HER-2单克隆抗体(赫赛汀)靶向治疗的一项辅助检测手段。 
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