Usage: A second generation sulfonylurea with hypoglycemic activity Biological Activity:ATP-dependent K + channel (K ATP ) and CFTR Cl - channel blocker. Inhibits K ATP currents in the pancreas, causing an increase in
intracellular Ca 2+ and insulin secretion. Inhibits recombinant
CFTR Cl- channels with an IC 50 of 20 μ M.
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